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Avoid simultaneous use with strong acids or chelators (e.g., vitamin C or retinol serums) because they can inactivate copper peptides

Call Your Provider Promptly For Severe abdominal pain (possible pancreatitis) Persistent vomiting that prevents fluid intake Right-upper-quadrant pain that radiates to the back or shoulder (possible gallbladder issue) Sudden vision changes (rare, but reported) Symptoms of severe dehydration: dizziness on standing, dark urine, dry mouth For a deeper dive on what to expect over time, our side effect timeline guide walks through duration and management for each common issue

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Tirzepatide is more effective for blood sugar control, and retatrutide was most effective in managing diabetic kidney disease and body weight