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The clinical significance of this effect varies between medicines and individuals

Figure 3 Clinical translation and human data taxonomy The translation of these mechanisms into human clinical data requires a strict evidence taxonomy to avoid conflating metabolic improvements with intrinsic disease modification

People with pancreatitis or gallbladder problems (including gallstones) should steer clear of Wegovy (4)

Treatment Benefits Reduce calorie intake without strict dietary restrictions Mounjaro has effects that suppress appetite and regulate blood sugar levels, so it is expected to help reduce calorie intake without strict diet restrictions