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In a randomized, controlled clinical study (Study E) in 570 adults with type 2 diabetes, LANTUS was evaluated for 52 weeks in combination with oral antidiabetic medications (a sulfonylurea, metformin, acarbose, or combinations of these drugs)

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Glycemic control, assessed by HbA1c, showed a trend toward lower values in the GLP-1 RA group (6.1% vs 7.0%, p = 0.08), which may have contributed to improved tear film stability and production, although this difference was not statistically significant and cannot solely explain the ocular surface differences

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