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Furthermore, colonic tissue from chronic constipation patients demonstrates oxidative stress damage, with increased reactive oxygen species (ROS) production, mitochondrial dysfunction, and increased apoptosis ( Kynurenine pathway activation is an important metabolic pathway connecting inflammation and depression

Given the potential risks and the lack of regulatory oversight, I strongly advise patients to use the brand-name drugs

The findings give multiple warning signs to us, and one of them is the current recommended B12 dose for pregnant women is too low, or at least insufficient