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The oral small-molecule route is suited to investigations where simple, time-of-day-independent administration and pure GLP-1 mono-activation are the focus

Sanofis results from the Phase 2 study showed that efdoralprin alfa, a recombinant human alpha-1 antitrypsin (AAT)-Fc fusion protein therapy met all primary and key secondary endpoints when dosed every 3 weeks or 4 weeks in adults with alpha-1 antitrypsin deficiency (AATD) emphysema (a rare disease), offering a more convenient and potentially more effective option

Now, for the administration itself

For those seeking to optimize longevity, peptides such as Epitalon and MOTS-c have shown promising results in extending cellular lifespan and improving mitochondrial function