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Another study in the Journal of the American Heart Association found that the risk of major cardiovascular events in people with elevated TMAO was 60% greater than for those with normal TMAO

While this warning is primarily based on rodent studies and has not been confirmed in humans, cagrilintide is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2)

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