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However, subsequent well-designed, randomized, placebo-controlled clinical trials with NAC 600 mg three times daily, combined with other medications or in monotherapy failed to provide evidence supporting the use of NAC in patients with IPF [31] and identified safety issues with the combination of prednisone, azathioprine, and NAC [30]

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Scientists claim that topical products act locally and generally have a low systemic absorption rate, which limits their ability to compromise the fetus