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The aggregates participate in initiating processes in which molecules of p53 widely unfold and then aggregate, resulting in the emergence of amyloid-containing structures
No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued
& de Cabod, R
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