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This triple receptor activity is the defining mechanistic feature that distinguishes Retatrutide from related compounds: Semaglutide acts on GLP-1R alone, while Tirzepatide targets GLP-1R and GIPR without glucagon receptor involvement

Risks include minor bruising or discomfort at the IV site, a rare risk of phlebitis (vein irritation), and the small but real risk of electrolyte imbalance if high doses are given without appropriate lab monitoring

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The answer, unfortunately, has to do with how insurance companies work