128 Impact of GLP-1RAs in Perioperative Period During the perioperative period, concerns have been raised regarding the use of GLP-1RAs and their potential association with an increased risk of bronchopulmonary aspiration due to delayed gastric emptying and retention of the gastric contents
These receptors activate the transcription of the human insulin receptor gene, thereby stimulating the expression of insulin receptors improving insulin-mediated glucose transport 14
Over-expressing anti-apoptotic Bcl2 factors has been shown to reduce HC death due to ototoxins (Cunningham et al., Purinergic Pathways Adenosine is an endogenous nucleoside present in all cells of the body that exerts its pharmacologic effects by activation of purine adenosine receptors, also present in the HCs, supporting Deiters cells and SGNs (Vlajkovic et al., 2007, 2009)
This article reviews current evidence, evaluates pharmacological and mechanistic safety profiles, summarizes recent cohort studies, and discusses clinical management strategies for preconception counselling and inadvertent exposure
