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Mouse models are highly effective in age related studies as the shortened timeline allows observation of the full impact of treatments in months as opposed to the years of human clinical trials

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However, in view of the recently described link between blood clots and brain fog in long COVID [67], it is of interest that choline administration has been reported to be neuroprotective in a range of animal models, and in the prevention of disseminated intravascular coagulation [68, 69]