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GLP-1s are certified blockbusters used by millions, but as The Post notes, there has been "comparatively less" study of what happens when users stop

For instance, HMGB1 can regulate calcium levels through a TLR4/ROS-dependent pathway, leading to calcium leakage from the sarcoplasmic reticulum, a reduction in the amplitude of calcium transients, and decreased cardiomyocyte contractility, which can further aggravate the pathological processes in the heart [307]