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Interestingly, we found that SLC7A11 mRNA is also a target of the IRE1 RIDD activity

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In the rabbit, two groups (one of 14 and one of 16 pregnant females) were exposed to an aerosol of 10% acetylcysteine and 0.05% isoproterenol hydrochloride for 30 or 35 minutes twice a day from the 6th through the 18th day of pregnancy

Similarly, penetration enhancers may facilitate drug permeation across the nasal epithelium but also have disruptive properties, resulting in undesired effects