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This can be replicated with Metformina drug used to treat type 2 diabetes that can lower levels of glucose in the body, enhance insulin sensitivity, and reduce symptoms of aging (11)

Once a vial is opened, refrigeration (28 C) is recommended per typical laboratory SOPs to extend usable life within the 28-day post-puncture window

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However, shGDH1 cells exhibited reduced de novo lipogenesis implicated by the [ 13 C]glucose tracing and lipidomic analysis (Supplementary Fig