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Cardio-cerebrovascular cell death is a fundamental pathological process and ferroptosis occurs during all periods of CCVDs

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Studies of the leukodystrophy Vanishing White Matter disease, in which mutations occur in subunits comprising the eukaryotic initiation factor 2B (eIF2B), demonstrate OL-directed cytotoxic function of astrocytes for reasons that are not completely understood 22

It is important to distinguish between side effects directly caused by a medication and symptoms that may occur coincidentally during treatment