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In addition, HDL and cholesterol efflux were reported to suppress megakaryocyte progenitor proliferation, platelet levels, and thrombocytosis (826)

Another second-line pharmacologic option is prucalopride, a 5-HT4 serotoninergic agonist, with an established dose applied orally every 24 hours.94,97 Prucalopride is a good option in patients that experience adverse effects related to GLP-1 agonists because it increases gastric emptying, augmenting rectal sensitivity and intestinal transit

It is highly purified sterile water containing 0.9% benzyl alcohol as a preservative

By disrupting this interaction, the peptide releases p53 to trigger apoptosis selectively in senescent cells while sparing healthy cells (Baar et al., 2017)