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The mean concentration/dose ratios (CDRs) of VPA were significantly higher in patients with the heterozygous CYP2C19*1/*2 genotype or compound heterozygous CYP2C19*2/*3 genotype than in patients with the homozygous CYP2C19*1/*1 genotype

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As industrialization and mass manufacturing techniques provided safer, more effective ways to produce drugs at scale, compoundings function in the drug supply chain rightly contracted to a much more limited, though important role serving patients whose needs cannot be met by commercially available medicines

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