Although PI3K pathway inhibitors reduce cancer growth, they could accidentally increase tumor invasion by inducing reprograming of mitochondrial trafficking, OXPHOS, and promoting cell motility (203)
Weight loss medications should support healthy, sustainable weight reduction, not compromise nutritional status or quality of life to an unacceptable degree
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Meanwhile, to further enhance the convenience of wound therapy and achieve controlled drug release, hydrogel-based (e.g., hyaluronic acid, alginate, and gelatin) delivery systems for drugs or exosomes can be established, providing an integrated intervention-delivery solution for precise regulation of ferroptosis in diabetic wounds [49, 87, 89, 98, 108]