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Since there is overlapping corticostriatal-limbic circuitry that regulates food intake and alcohol consumption (Volkow et al., 2009, 2012b

Naturally occurring variation in GLP1R cannot replicate that level of activation, which is why we don't see GLP1R variants with dramatic effects on BMI

If you are concerned about testosterone stability while on GLP-1 therapy, work with your endocrinologist or primary care physician to monitor levels every 48 weeks during initial semaglutide therapy and adjust your testosterone dose if needed

Martinez 6,7 , Maria Galn 8,9* , Affiliation: 1 Group of Endocrinology, Diabetes and Nutrition, Institut de Recerca Sant Pau, 08041 Barcelona, Spain 2 CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain Email: [email protected] ORCID: Josep Julve 1,2* Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a complex chronic metabolic dysfunction of the liver influenced by both genetic and non-genetic factors [1]