Conclusion Semaglutide represents a revolutionary approach to weight loss, providing significant benefits for those struggling to achieve their goals
On one hand, the cardiovascular protection afforded by SGLT2is seems to result from their beneficial hemodynamic effects, including improvement in ventricular preload (secondary to natriuresis and osmotic diuresis) and afterload (through blood pressure reduction), but also from improvement of cardiac metabolism (through the switch from utilization of glucose to ketones), inhibition of the myocardial Na + /H + exchanger, reduction of cardiac fibrosis and necrosis, reduction of proinflammatory adipokines derived from epicardial and perivascular fat, and stimulation of erythropoiesis (which can facilitate the release of oxygen to ischemic tissues) [1, 4, 14,15,16]
Inhibitors of FAK that target the ATP-binding pocket of the kinase domain have been largely unsuccessful 10,11 , displaying micromolar anti-proliferative effects and no apoptotic effects in cancer cells despite reported nanomolar biochemical potencies for the FAK enzyme 12,13
Nutrigenomics is an up and coming new trend
