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Excretion Pathways Radiolabeled studies in humans established PT-141s elimination pathways: 64.8% of administered dose recovered in urine 22.8% of dose recovered in feces Complete elimination occurring within several days No evidence of accumulation with repeated administration The predominantly renal excretion pattern and absence of accumulation support the approved dosing regimen of no more than one dose per 24 hours and maximum eight doses per month

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PMID: 38320624 J Cell Mol Med Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1