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In this context, earlier studies in mouse models of obesity indicated an involvement of the transcription factor p53 in regulating adipocyte stress responses that might signal to recruit macrophages 23

This gives us a clear target that would eliminate two birds with one stone, eliminating senescent cells and keeping neighboring cells healthy for longer. Unrelated to the Salk study, scientists have already developed drugs to target acid ceramidase for the treatment of other diseases in which this enzyme also plays a role