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In conclusion, most animal studies support a beneficial effect of GLP-1RAs on NAFLD histology, including steatosis and inflammation, but not on fibrosis, while a few initial animal studies with GLP-1RA related polypeptides have provided limited evidence for a more favorable effect of peptide polyagonists on hepatic fibrosis

Advanced fibrosis was defined as presence of histologic fibrosis stage F3

Engineered probiotics introduced to improve intestinal microecology for the treatment of chronic diseases: present state and perspectives

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