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Results: This analysis across 4 trials includes 121 participants (100 CHB, 21 CHD) who received a median of 10 doses each of tobevibart and elebsiran Q4W

Stop or switch in consultation with your prescriber if any of the following appear despite hitting the 7 rules above: hand-grip strength drops more than 10% from baseline, you cannot climb one flight of stairs without significant fatigue, a 6-month DEXA shows more than 25% of total weight loss as lean mass, or you are losing more than 1.5% of bodyweight per week despite eating 1.6 g of protein per kilogram

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Even with good hydration and fiber intake, the reduced transit speed can still contribute to less frequent bowel movements