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"Morning is the only way to go." "Evening changed my life." "Friday injection is the best." And they are all correct, for themselves

Available case reports demonstrate plausibility, but large observational studies are needed to estimate actual risk

This reduction is key for inhibiting the enzymatic activity of 15-lipoxygenase, primarily by converting its non-heme Fe3+ to an inactive Fe2+ state

Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]