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J Park Dis 7:619628 Antonini A et al (2007) Duodenal levodopa infusion for advanced Parkinsons disease: 12-month treatment outcome

Drink alcohol very often, or drink a lot of alcohol in short-term "binge" drinking

2 The native hormone has a serious pharmaceutical liability: it is prone to aggregation into amyloid fibrils and has a plasma half-life measured in minutes, which is why the first amylin-based drug, pramlintide, had to be injected before every major meal