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Vamifeport (VIT-2763), as a novel oral FPN inhibitor, induces dose-dependent internalization and ubiquitination of FPN in cells, improving iron homeostasis in mouse models of -thalassemia

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[14] The identity of the receptor or receptors that mediate these E-peptide effects remains, as of the current literature, unresolved and, as the in-vivo work discussed below shows, the claim of full IGF-1R independence is itself contested by studies in which E-peptide-driven hypertrophy did require the receptor

Tirzepatide maintenance: the SURMOUNT-4 evidence The SURMOUNT-4 trial used a randomized-withdrawal design: all participants took open-label tirzepatide for 36 weeks (reaching a mean weight reduction of about 20.9%), then were randomized either to continue the drug or switch to placebo for another 52 weeks