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After lipid uptake, acyl-CoA: cholesterol acyltransferase 1 (ACAT1) catalyzes cholesterol esterification

Some patients start with semaglutide because coverage is easier to obtain, then switch to tirzepatide if results plateau or if coverage changes

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A thorough medical evaluation is necessary to determine eligibility. While there is no strict diet required, focusing on nutrient-dense foods and reducing intake of high-fat and high-sugar (high-calorie, less satiating) items can improve outcomes and minimize side effects. MBBS (Hons), FRACP (Australia) Dr Dinesh graduated with honours from Monash University, Melbourne in 2009, receiving the Prince Henry's Prize in Surgery