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Moreover, astrocytes in AD often exhibit impaired phagocytic capacity and defective immune clearance, resulting in the accumulation of neuronal debris and secondary iron release, further exacerbating local cytotoxicity and iron dyshomeostasis (Zeng et al., 2025)

When you feel good about how you look, it can reduce stress, improve sleep, boost motivation, and support emotional balance

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Dysregulation of ERAD can lead to the accumulation of misfolded proteins, chronic ER stress, and ultimately, cardiac dysfunction