when did the first glp 1 come out weight loss drugs came in the 1890s Then, in the 1930s, sliming drugs were more widely used: DNP and Benzedrine Later came orlistat and sibutramine Now we have GLP-1 Glucagon-like peptide-1 receptor: mechanisms and

Two weeks after taking 0.5 mg, one patient reported that she hadnt felt well in a decade, was able to eat foods she hadnt been able to tolerate, could go to a restaurant again, and had even gone for a hike

Less Common but Serious Side Effects Some less common but more serious GLP-1 side effects are worth being aware of: Pancreatitis (inflammation of the pancreas) Gallbladder problems (including gallstones) Acute kidney injury (usually as a result of severe dehydration from vomiting or diarrhea) Diabetic retinopathy worsening (particularly in patients with rapid improvement in blood sugar control) Hypoglycemia (when combined with other diabetes medications like sulfonylureas or insulin) All GLP-1 medications also carry a warning regarding a theoretical risk of medullary thyroid carcinoma, based on animal studies

Injectable semaglutide (once weekly) remains more potent for weight loss than current oral peptide formulations, but oral agents may be preferable for individuals who avoid needles

Lift weights that feel challenging in the 8-12 rep range