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At the same time, tissue inhibitors of metalloproteinases (TIMPs) increase across all tested concentrations

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If BBB integrity is impaired during disease onset or progression, neuronal tissue will be exposed to detrimental substances circulating in the blood and thereby may accelerate progression of the disease, as further discussed in the Section Evidence for a role of BBB alterations in disease pathogenesis

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Ensure there are no large air bubbles in the syringe by gently tapping the side and pushing the plunger slightly

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