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Considering the multifactorial pathogenesis of OA, future research needs to prioritize conducting early proof-of-concept clinical trials to evaluate the feasibility and synergistic effects of locally applied ferroptosis inhibitors such as Fer-1 or GPX4 activators combined with existing conservative treatments including weight management, physical therapy, and NSAIDs or emerging cell and tissue engineering therapies
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The results showed that a combined lower dose of each, provided a safe, yet effective, alternative for Botox: An activecontrolled trial, compared cream containing 5% leuphasyl solution (0.05%), cream containing 5% Argireline solution (0.05%) and combination
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