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DPP4i are all small molecules that inhibit the catalytic activity of the enzyme without affecting any of the other known functions of the DPP4 protein

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Research Highlight Published: GLP-1 receptor agonism Nature Aging volume 6 , pages 2728 (2026) Cite this article 725 Accesses 1 Citations 2 Altmetric Metrics details Subjects Regarding the recently announced failure of a GLP-1RA trial in clinical stage Alzheimers disease, we believe this highlights the need for a strategic shift, not an abandonment of the drug class in neurodegeneration, says Ho Ko, co-corresponding author of the study