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To corroborate our spatial transcriptomics data, we assessed therapeutic effects on beta cell dedifferentiation by CD81 immunostaining, as CD81 is normally restricted to alpha cells but marks dedifferentiated beta cells (Fig

Schematic illustrating the process of xenobiotic metabolism, which encompasses three phases I, II, III (Adopted from [137]) as well as xenobiotic induced oxidative stress and molecular damage

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In the fox-odor container test, 3xTg mice exhibit increased predator odor-induced anxiety, which is detectable at 2 months of age (i.e., before the onset of AD pathology) and is more pronounced in aged females than males (Szab et al., 2023)