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Two years ago, researchers examining the link between GLP-1 and substance abuse began to publish large, observational studies showing that patients taking GLP-1s for their prescribed purposes incidentally reported less alcohol, opioid, cannabis and cigarette use and had a lower risk of developing a substance use disorder

This is likely explained by our previous finding that, compared with normal tilapia, CPT1 is overexpressed in MD-treated tilapia as a compensatory response to carnitine deficiency and the associated low -oxidation capacity ( Reference Pan, Li and Li 34 )

As such, GLP-1 receptor (GLP-1R) agonists have become a major therapeutic option for the management of hyperglycemia in patients with diabetes