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Sato T, Azuma Y, Ozone C, Okazaki M, Takeda A, Okada M, Futamura K, Hiramitsu T, Goto N, Narumi S, et al

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It is believed to work through several pathways: Blocking voltage-dependent sodium channels , reducing neuronal excitability Enhancing GABA (gamma-aminobutyric acid) activity , an inhibitory neurotransmitter Antagonising glutamate receptors , further dampening excitatory neurotransmission Inhibiting carbonic anhydrase enzymes , though the clinical significance of this effect varies Topiramate is taken orally, typically once or twice daily

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