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Peptides with sequences rich in hydrophobic residues, or those with a high proportion of basic amino acids (lysine, arginine, histidine) that require protonation for charge-mediated aqueous solubilisation, typically reconstitute cleanly and completely in 0.1% acetic acid water whereas the same peptides may form aggregates, gels, or turbid suspensions when reconstitution with neutral sterile water or bacteriostatic water is attempted first

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Notably, genes involved in the TSS pathway, cystine uptake and glutathione recycling (such as CBS, CSE, SLC7A11 and GSR) were DNA hypomethylated after DMF treatment 30 , supporting a regulatory effect of DMF on these pathways