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Conversely, increasing the relative proportion of monounsaturated acyl chains at the expense of polyunsaturated lipids suppresses sensitivity to ferroptosis 20,21

This vicious cycle of energy depletion, anaerobic shift, and lactic acidosis creates a biological trap that keeps patients locked in a state of chronic exhaustion, highlighting the critical need to restore aerobic mitochondrial function

Conclusions The findings suggest that the benefits of semaglutide on cardiovascular and kidney outcomes were unaffected by the concomitant use of SGLT2i