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PMS is widely linked to Carneys complex which is associated with pigmented skin lesions (lentiginous or blue naevi), myxomas (in the heart, skin, and breast), multiple functional endocrine (primary pigmented nodular adrenocortical hyperplasia and pituitary) and non-endocrine (testicular) neoplasms, and unusual type of psammomatous melanotic schwannomas [4, 21]

Raw data from the epiproteomics datasets are in Supplementary Table 3

This would result in the formation of neurofibrillary tangles (NFTs) and the subsequent disruption of normal neuronal and synaptic functions [95]

Notably, the proteomic signatures identified in the renal artery of Glp1r VSM+/+ mice were completely absent in Glp1r VSM/ mice, consistent with the loss of semaglutide-induced hemodynamic and renal effects in these animals (Figure 6, DG)