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That framing has clinical grounding: a 2023 analysis in Obesity Reviews noted that sex-specific differences in GLP-1 receptor sensitivity and adipose distribution influence both drug response and side-effect burden

Diagnosis and Differential Diagnosis The diagnosis of DN is made by clinical recognition of typical distinctive lesions (see Table 12-1), and diagnostic accuracy is considerably improved by dermoscopy

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Nonetheless, there is currently no sufficient information concerning drug or chemical distribution within tissues based on such data, highlighting the need for further research on this issue [18,19,20,21,22]