topiramate and semaglutide Day 8: Qsymia (Phentermine + ER) Class: Sympathomimetic + Anticonvulsant FDA Approved: 2012 Avg Weight Loss: 6.7β8.9% over placebo Pros: Synergistic appetite suppression Gradual titration Cons: Teratogenic (must avoid in pregnancy) π’ ACP Obesity Guidelines 2026
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