tirzepatide long-term side effects Long Term Effects: Clinical Context – PlexusDx Is Tirzepatide Safe Long Term?

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The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]

GLP-1s are notorious for their side effects

Knibbe CA, Krekels EH, van den Anker JN et al , Morphine glucuronidation in preterm neonates, infants and children younger than 3 years