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doi: 10.1111/DME.15248 [DOI] [PubMed] [Google Scholar] 71.Jensterle M, Ferjan S, Vovk A, et al

Act on the brain to decrease hunger, increase satisfaction, and alter the food-reward system (changing food preferences in favor of healthier options.) Improves the bodys response to insulin, a term called insulin sensitivity, which positively affects blood sugar levels and weight loss

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SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks