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Thus, the overexpression of ACE2 not only is related to the upregulation of AT 2 R and Mas receptors but also to the downregulation of AT 1 R and ACE ( Ang-(17) is associated with reduced depressive and anxious behaviors as a selective non-competitive antagonist of Ang II at type 1 Ang II receptors ( Centrally injecting the MasR antagonist reverses the ACE2 and Ang-(17)-induced anxiolytic effects, indicating the anxiolytic effects of ACE2/Ang-(17)/MasR pathway due to activate Mas receptors ( 3.3 RAS blockers-induced mood-elevating effects ACEIs and ARBs have been shown to have protective and potential therapeutic benefits in mood disorders ( Table 2 )