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However, under pathophysiological conditions, especially during APAP overdose, excessive NAPQI accumulates and binds to cellular proteins, also triggering oxidative stress, leading to hepatocellular damage and the release of damage-associated molecular patterns (DAMPs), contributing to further liver injury and inflammation

Matt Segar, MD, points out, changes in biomarkers do not necessarily translate to clinical benefit. Skin health and UV exposure Astaxanthin naturally accumulates in the skin, where it can help absorb UV light and counteract the oxidative stress that leads to visible aging

International Journal of Molecular Sciences, 24(8), 4567-4582.

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