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Primary mechanisms: Type I, III, VI collagen upregulation (70%+ increase in fibroblast models)

Discussion The BBB poses a significant impediment to drug delivery, with over 98% of pharmaceutical agents unable to efficiently traverse it, thereby diminishing their therapeutic efficacy in treating various neurological disorders, including neurodegenerative diseases 35

Randomized trial of peribulbar triamcinolone acetonide with and without focal photocoagulation for mild diabetic macular edema: a pilot study

Since MTHFR controls the detoxification of homocysteine and the supply of methyl groups for SAM synthesis, a reduction in its activity can affect homocysteine metabolism and disturb cellular methylation processes