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Hypoglycemic Effect The phase III (SURPASS) program is a class of trials designed to evaluate the efficacy and safety of tirzepatide in the treatment of patients with type 2 diabetes

However, using variants that do not dimerize, it has been recently described that homodimer formation of GCL is not required for enzyme activation (Yang et al., 2019)

J Cell Biol 179: 389395 BraunNA,MorganB,DickTP,SchwappachB (2010) The yeast CLC protein counteracts vesicular acidification during iron starvation