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Early data further suggest Retatrutide might offer neuroprotective benefits, possibly due to improved metabolic health and reduced systemic inflammation, pointing to a broader therapeutic potential in preserving cognitive function and preventing dementia

The company's stock was down about 15% in mid-day trading on Tuesday following the unexpected Q1 loss

Although patients enrolled in both trials were at high cardiovascular risk, patients with symptomatic HF or those receiving medications for HF were excluded, making these findings more concerning

Furthermore, healthcare providers must ensure that patients are fully informed about the off-label nature of the treatment, the potential risks, and the lack of FDA approval for the specific use in question