glp-1 response Signaling pathways triggered in to receptor activation Favorable Effects of GLP-1 Receptor

individuals with mild-to-moderate type 2 diabetes (A1C 7-9%)

Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes

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The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) ( Figure 2 )