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We also calculated the standardized absolute risk for any dementia to investigate whether our findings may be specific to Alzheimer's disease

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At lower concentrations (nanomolar to micromolar), KYNA facilitates -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) responses, whereas at higher concentrations (millimolar), KYNA antagonizes AMPAR activity [29]

Like ADC, CAR-T cells therapy needs to be very specific because of the risk of off-target that could lead to strong side effects even though expected results should be potentially higher regarding its long-term efficacy